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MYP_055878
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Basic Information
Antimicrobial peptide PNG-1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
12 amino acids
C68H112N18O14
Standard
Sequence
LNWGAILKHIIK
Physicochemical Analysis
1405.73 Da
10.00
1.85
1.59
0.1538
0.59
0.57
0.33
23.32
170.83
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
523.02
-0.56
18.0
17.0
47.0
100.0
3.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0118616 VERIFIED: YES
Provenance & Taxonomy
Panurgus calcaratus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
10.6 μM
MIC
PMID23483218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23483218/
RECORD: Rec_0124200 VERIFIED: YES
Provenance & Taxonomy
Panurgus calcaratus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
1.5 μM
MIC
PMID23483218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23483218/
RECORD: Rec_0125115 VERIFIED: YES
Provenance & Taxonomy
Panurgus calcaratus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
1.3 μM
MIC
PMID23483218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23483218/
RECORD: Rec_0137291 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0140912 VERIFIED: YES
Provenance & Taxonomy
Panurgus calcaratus [Animal]
Panurgine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperAmino Acids. 2013 Jul;45(1):143-57. | http://www.ncbi.nlm.nih.gov/pubmed/23483218 PMID23483218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23483218/
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