Peptide Database

Peptide NameCono-RFamide-Vc1

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC101H147N31O22

DescriptionStandard

        HSGFLLAWSGPRNRFVRF
    

Molecular Weight2147.44 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.85

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.1582

GRAVY Index-0.17

Hydrophobic Moment 0.41

Boman Index0.01

Instability Index12.11

Aliphatic Index 65.00

Aromaticity 0.2222

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 862.95

LogP -6.76

H-bond Donors 32.0

H-bond Acceptors 26.0

Rotatable Bonds 65.0

Heavy Atoms 154.0

Ring Count 7.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042635 VERIFIED: NO

Provenance & Taxonomy

OrganismConus victoriae [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0048153 VERIFIED: YES

Provenance & Taxonomy

OrganismConus victoriae [Animal]

FamilyConorfamide-Vc1

Tax ID319920

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation ACE inhibitory Pruriceptive

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0261911 VERIFIED: YES

Provenance & Taxonomy

OrganismConus victoriae [Animal]

FamilyConorfamide-Vc1

Tax ID319920

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation ACE inhibitory Pruriceptive

Targetcoupled receptors

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0263859 VERIFIED: YES

Provenance & Taxonomy

OrganismConus victoriae [Animal]

FamilyConorfamide-Vc1

Tax ID319920

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation ACE inhibitory Pruriceptive

Activity1.8 μM

MethodEC50

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0368487 VERIFIED: YES

Provenance & Taxonomy

OrganismConus victoriae [Animal]

FamilyConorfamide-Vc1

Tax ID319920

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation ACE inhibitory Pruriceptive

Targeta specific subset of DRG neurons

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour