Peptide Database

Peptide NameSLAY-screened peptide P5718

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H161N33O31S2

DescriptionStandard

        MYLYDNNFHYNCIRLSHSRA
    

Molecular Weight2517.80 Da

Isoelectric Point (pI)7.98

Net Charge (pH 7.0)0.66

Net Charge (pH 7.4) 0.33

Charge Density (pH 7.0) 0.0331

GRAVY Index-0.69

Hydrophobic Moment 0.41

Boman Index-0.12

Instability Index55.83

Aliphatic Index 63.50

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1065.10

LogP -9.92

H-bond Donors 39.0

H-bond Acceptors 36.0

Rotatable Bonds 79.0

Heavy Atoms 177.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426919 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/