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MYP_055801
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Basic Information
pVEC mutant
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C98H177N37O21
Standard
Sequence
LLIILRRRIRKQAHAHSK
Physicochemical Analysis
2209.69 Da
12.00
5.93
5.63
0.3296
-0.44
0.58
-0.35
98.19
141.11
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
978.34
-7.54
37.0
29.0
79.0
156.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0113455 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled with fluorescein
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0114578 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
pVEC
10090
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Fluorescein/FITC labeling
Amidation
N-term detail: Labelled with fluorescein; lowercase source residues at positions 13 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide
Human bowes melanoma cells
Fluorescence-based uptake assay
PMID16808894 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16808894/
RECORD: Rec_0132797 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
PVEC
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cell-penetrating peptide Antiparasitic Antimalarial
Plasmodium falciparum HB3
PLDH assay
PMID18519720 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18519720/
RECORD: Rec_0165848 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
PVEC
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cell-penetrating peptide Antiparasitic Antitrypanosomal
Trypanosoma brucei brucei 427
Alamar Blue assay
PMID18519720 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18519720/
RECORD: Rec_0178127 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cell-penetrating peptide
Human erythrocytes
200 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21956793/ PMID21956793 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21956793/
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