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MYP_055771
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Basic Information
DefDM
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
38 amino acids
C173H277N63O50S6
Standard
Sequence
GFGCPLNQGACHNHCRSIRRRGGYCSGIIKQTCTCYRN
Physicochemical Analysis
4231.83 Da
9.43
5.87
5.48
0.1545
-0.61
0.72
-0.19
86.58
43.68
0.0789
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1860.94
-26.17
73.0
64.0
138.0
292.0
6.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0136553 VERIFIED: YES
Provenance & Taxonomy
Dermacentor marginatus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (<5% Hemolysis at 25 microM
25 μM
Hemolysis
PMID24747431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24747431/
RECORD: Rec_0164728 VERIFIED: YES
Provenance & Taxonomy
Dermacentor marginatus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
3 μM
MIC
PMID24747431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24747431/
RECORD: Rec_0189903 VERIFIED: YES
Provenance & Taxonomy
Dermacentor marginatus or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
0.5-3 μM
MIC
PaperDefensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
RECORD: Rec_0192115 VERIFIED: NO
Provenance & Taxonomy
Dermacentor variabilis [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-25; 11-33; 15-35
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0208068 VERIFIED: YES
Provenance & Taxonomy
Dermacentor marginatus or [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Micrococcus luteus
0.2 μM
MIC
PaperDefensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
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