Peptide Database

Peptide NameMT-SC19EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC126H193N27O39S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELI
    

Molecular Weight2742.10 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-3.49

Net Charge (pH 7.4) -3.72

Charge Density (pH 7.0) -0.1660

GRAVY Index-1.21

Hydrophobic Moment 0.64

Boman Index-0.18

Instability Index66.09

Aliphatic Index 74.29

Aromaticity 0.1429

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1102.77

LogP -3.63

H-bond Donors 38.0

H-bond Acceptors 37.0

Rotatable Bonds 96.0

Heavy Atoms 193.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296429 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 HXB2:inhibition of cell-cell fusion in TZM-bl cells

Activity0.0049±0.0015 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0314495 VERIFIED: YES