Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length570 amino acids

Chemical FormulaC2867H4458N726O838S24

DescriptionStandard

        MGLMPYKRGSREIPGSLHCVRTQPEGADYEPGKRDHAGSLILDFPASRTVSSKFLLFICYSSPNRLTVTNIFFHQNVSSSWVQGSSGEHIVSKAEGIEGTPQLWMLPRLEMRTKAVQVLWGCFFLWNLCSSSTQTIYPGIKARVTQRALDYGIQAGMEMIEQMIKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGEADLFLSGVYFTGIIVLSQNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPLDNLTDPPFLPVPFALPERSDSMLYVGISEFFFKSASFAYFIAGAFNVTLSMKEISNHLVQNSQGLGNMLSRIAEIYILSQPFMVRVMATEPPVISLLPGNFTLDIPASIVILTQPENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESSRSNIEGFLLISTDLKYETSLKQQPSFHGWEGLSLMSGQWRGKPAA
    

Molecular Weight63273.98 Da

Isoelectric Point (pI)5.41

Net Charge (pH 7.0)-11.62

Net Charge (pH 7.4) -12.58

Charge Density (pH 7.0) -0.0204

GRAVY Index0.07

Hydrophobic Moment 0.68

Boman Index0.15

Instability Index39.24

Aliphatic Index 96.11

Aromaticity 0.1018

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65695.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322745 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria