Peptide Database

Peptide NameInsulin Lispro

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic

Standard StatusStandard

Sequence Length51 amino acids

Chemical FormulaC257H387N65O76S6

DescriptionStandard

        GIVEQCCTSICSLYQLENYCNFVNQHLCGSHLVEALYLVCGERGFFYTKPT
    

Molecular Weight5795.60 Da

Isoelectric Point (pI)5.39

Net Charge (pH 7.0)-2.12

Net Charge (pH 7.4) -2.52

Charge Density (pH 7.0) -0.0415

GRAVY Index0.22

Hydrophobic Moment 0.44

Boman Index0.18

Instability Index10.85

Aliphatic Index 85.88

Aromaticity 0.1373

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2264.85

LogP -20.89

H-bond Donors 83.0

H-bond Acceptors 82.0

Rotatable Bonds 185.0

Heavy Atoms 404.0

Ring Count 10.0

Amide Bonds 56.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216942 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideA6-A11, A7-B7, A20-B19

Other ModsLysB28/ProB29 inversion relative to human insulin

Bio-Activity Profile

Function

Antidiabetic Hypoglycemic Insulin analog

Half-LifeOn subcutaneous administration = 1 h

PaperPubMed-linked source references: PMID:18454569; PMID:20424816; PMID:19496630; PMID:18076215; PMID:17764465; PMID:17703632; PMID:16706558; PMID:11118018 PMID18454569;20424816;19496630;18076215;17764465;17703632;16706558;11118018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18454569/ PatentUS5474978