Peptide Database

Peptide NameSLAY-screened peptide P140

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H162N30O32S3

DescriptionStandard

        TVPRSERCRYCQLTDYLFSC
    

Molecular Weight2440.78 Da

Isoelectric Point (pI)7.64

Net Charge (pH 7.0)0.37

Net Charge (pH 7.4) 0.13

Charge Density (pH 7.0) 0.0185

GRAVY Index-0.46

Hydrophobic Moment 0.40

Boman Index-0.23

Instability Index55.72

Aliphatic Index 53.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1032.20

LogP -11.07

H-bond Donors 41.0

H-bond Acceptors 36.0

Rotatable Bonds 76.0

Heavy Atoms 169.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007134 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/