Peptide Database

Peptide NameBrain natriuretic peptide 34

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC164H279N55O43S4

DescriptionStandard

        LRSPKMMHKSGCFGRRLDRIGSLSGLGCNVLRKY
    

Molecular Weight3837.57 Da

Isoelectric Point (pI)10.96

Net Charge (pH 7.0)6.82

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.2007

GRAVY Index-0.39

Hydrophobic Moment 0.78

Boman Index-0.19

Instability Index94.06

Aliphatic Index 77.35

Aromaticity 0.0588

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1612.61

LogP -17.46

H-bond Donors 62.0

H-bond Acceptors 55.0

Rotatable Bonds 133.0

Heavy Atoms 266.0

Ring Count 4.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0079315 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyBrain natriuretic peptide

Tax ID9615

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0235258 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0340807 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis familiaris [Animal]

FamilyNatriuretic peptide

Tax ID9615

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Cardiovascular