Peptide Database

Peptide NameSLAY-screened peptide P1812

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC74H101N23O19

DescriptionStandard

        HYPRIDHNFRDF
    

Molecular Weight1616.74 Da

Isoelectric Point (pI)6.92

Net Charge (pH 7.0)-0.06

Net Charge (pH 7.4) -0.37

Charge Density (pH 7.0) -0.0054

GRAVY Index-1.56

Hydrophobic Moment 0.61

Boman Index-0.36

Instability Index50.71

Aliphatic Index 32.50

Aromaticity 0.2500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 693.71

LogP -5.00

H-bond Donors 24.0

H-bond Acceptors 21.0

Rotatable Bonds 48.0

Heavy Atoms 116.0

Ring Count 6.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393386 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/