Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length364 amino acids

Chemical FormulaC1853H2871N475O522S17

DescriptionStandard

        MMARPYCVVVALLLLAEVTRFGEGTPNPEIVGKITRKGLKYARQYGIATLKKELSAIKLPDFSGSFRICLIGNVNYVFSGLRIRRFVLLNSNLRLHTEQGIRASLFNNYVSVSGNWKVQKSFVNLYGTFDLSVDDISISVSLNFGKDQSGQPTASLTHCSNSIGQVSIEISGYLSWILNLFNERIENITFVADMFFCLQGEFFGQNGSFSVPFDAPLIRLPEKHDYMIYFAVSEYVFNMASRVYHQAGLMNFTIQNKHSFETSPESAPFLMFTPGNVTFMPVMDIQAFALMPNSSDCKALFHLRAVVLMESILNDYALHIIYPTLNAKLEEGSPLPLPKDIYLNSLELQVHKVSEKCSLGGGAL
    

Molecular Weight40699.59 Da

Isoelectric Point (pI)7.07

Net Charge (pH 7.0)0.17

Net Charge (pH 7.4) -0.62

Charge Density (pH 7.0) 0.0005

GRAVY Index0.14

Hydrophobic Moment 0.83

Boman Index0.15

Instability Index39.48

Aliphatic Index 97.20

Aromaticity 0.1154

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32235.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296828 VERIFIED: NO

Provenance & Taxonomy

OrganismCamelus dromedarius [Animal]

FamilyBPI

Tax ID9838

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence