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MYP_055419
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Basic Information
TP1[K1A]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C96H147N33O20S4
Standard
Sequence
AWCFRVCYRGICYRRCR
Physicochemical Analysis
2211.66 Da
9.69
4.75
4.50
0.2797
-0.18
0.60
-0.32
13.22
45.88
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
894.67
-6.59
40.0
29.0
68.0
153.0
5.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134703 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0139526 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Cryptococcus neoformans ATCC 208821
0.25 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0148106 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
C.neoformanas ATCC 208821
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0161511 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Acinetobacter baumannii ATCC 19606
0.125 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0179766 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae ATCC 700603 (MDR)
0.125 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
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