Peptide Database

Peptide NameNeutrophil antibiotic peptide NP-4 (Microbicidal peptide NP-4)

Function Ontology

Antimicrobial

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC429H711N133O137S8

DescriptionStandard

        MRTLALLAAILLVTLQAQAELHSGMADDGVDQQQPRAQDLDVAVYIKQDETSPLEVLGAKAGVSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR
    

Molecular Weight10180.56 Da

Isoelectric Point (pI)6.69

Net Charge (pH 7.0)-0.37

Net Charge (pH 7.4) -0.79

Charge Density (pH 7.0) -0.0039

GRAVY Index-0.01

Hydrophobic Moment 0.53

Boman Index-0.01

Instability Index54.44

Aliphatic Index 89.37

Aromaticity 0.0316

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4366.45

LogP -52.81

H-bond Donors 159.0

H-bond Acceptors 147.0

Rotatable Bonds 342.0

Heavy Atoms 707.0

Ring Count 7.0

Amide Bonds 102.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0122076 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9986

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Non-hemolytic