Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length55 amino acids

Chemical FormulaC277H440N70O86S5

DescriptionStandard

        MENEKYLQVVEDEELEQLVGGIGPGYIETLTKDCPRVTPQICLPINGIWTCKRCY
    

Molecular Weight6287.20 Da

Isoelectric Point (pI)4.48

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.82

Charge Density (pH 7.0) -0.0822

GRAVY Index-0.28

Hydrophobic Moment 0.66

Boman Index0.04

Instability Index42.92

Aliphatic Index 92.00

Aromaticity 0.0727

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10220.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2509.97

LogP -20.13

H-bond Donors 87.0

H-bond Acceptors 87.0

Rotatable Bonds 206.0

Heavy Atoms 438.0

Ring Count 9.0

Amide Bonds 59.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425382 VERIFIED: NO

Provenance & Taxonomy

OrganismBacillus cereus [Bacterium]

FamilyLantibiotic

Tax ID1396

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence