Peptide Database

Peptide NameSLAY-screened peptide P2949

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC65H98N20O18S

DescriptionStandard

        PWGSTYTMRQPR
    

Molecular Weight1479.66 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.96

Net Charge (pH 7.4) 1.90

Charge Density (pH 7.0) 0.1631

GRAVY Index-1.55

Hydrophobic Moment 0.32

Boman Index-0.31

Instability Index10.58

Aliphatic Index 0.00

Aromaticity 0.1667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 624.24

LogP -6.74

H-bond Donors 24.0

H-bond Acceptors 21.0

Rotatable Bonds 43.0

Heavy Atoms 104.0

Ring Count 5.0

Amide Bonds 12.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0405457 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/