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MYP_055315
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Basic Information
Mag(i +4)10
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
23 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GIGKFLHSAKXFGKXFVGEIXNS
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012748 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S5 stapling amino acid at 11,15; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
4.42 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0144849 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S5 stapling amino acid at 11,15; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus cereus
4.42 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0317445 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Contains X placeholder residue(s)
Bio-Activity Profile
Antimicrobial
PaperPatent US 10464975 B2 Evidence URLhttps://patents.google.com/patent/US10464975B2/en PatentUS 10464975 B2
RECORD: Rec_0355969 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S5 stapling amino acid at 11,15; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
14.87 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0373163 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S5 stapling amino acid at 11,15; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
8.84 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
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