‹ ›
MYP_055247
← PREVIOUS NEXT → BACK
Basic Information
Dermaseptin-S1 (1-29)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C133H226N36O35S2
Standard
Sequence
ALWKTMLKKLGTMALHAGKAALGAAADTI
Physicochemical Analysis
2953.57 Da
10.00
2.88
2.63
0.0993
0.52
0.51
0.27
-0.67
108.28
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1124.66
-8.37
40.0
41.0
100.0
206.0
3.0
28.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0172448 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0241332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of virus infection in Vero cells
1.7 μM
IC50
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0251489 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal
Staphylococcus aureus Cowan 1
1.5 μM
LD50
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0311345 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1 | Vero cells
1.7 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro activity of dermaseptin S1 derivatives against genital pathogens. | Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R. | APMIS. 2010 Sep 1;118(9):674-80. | DOI:10.1111/j.1600-0463.2010.02637.x | PMID:20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0378696 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal
Escherichia coli HB101
2.7 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
FIRST PREV 1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 3 of 4