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MYP_055152
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Basic Information
Somatostatin-14
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glucagon secretion inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide
Enzyme modulation ▸ Enzyme inhibition ▸ Insulin secretion inhibition
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
14 amino acids
C76H106N18O19S2
Standard
Sequence
AGCKNFFWKTFTSC
Physicochemical Analysis
1639.89 Da
8.91
1.77
1.55
0.1267
0.03
0.32
0.14
30.65
7.14
0.2857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
613.23
-5.45
24.0
23.0
50.0
115.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198442 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Somatostatin
9913
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Bos taurus): PMID 6117506 PMID6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6117506/
RECORD: Rec_0207355 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
Somatostatin
9940
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator Receptor modulation
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Ovis aries): PMID 6117506 PMID6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6117506/
RECORD: Rec_0209316 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Somatostatin
10116
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator Receptor modulation
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Rattus norvegicus): PMID 6117506 PMID6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6117506/
RECORD: Rec_0210348 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.4%, E 0.0%, T 35.7%, C 42.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication Hormones
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0214483 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]; Homo sapiens [Animal]; Mus musculus [Animal]; Rattus norvegicus [Animal]
Somatostatin
9913; 9606; 10090; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
3-14
Bio-Activity Profile
Hormonal Neurotransmitter
Posterior hippocampus tissue homogenate (SDAT brain)
Radioimmunoassay
79.8 ± 11.1 min
PaperMetabolic half-life of somatostatin and peptidase activities are altered in Alzheimer's disease
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