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MYP_055152
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Basic Information
Somatostatin-14
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glucagon secretion inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide
Enzyme modulation ▸ Enzyme inhibition ▸ Insulin secretion inhibition
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
14 amino acids
C76H106N18O19S2
Standard
Sequence
AGCKNFFWKTFTSC
Physicochemical Analysis
1639.89 Da
8.91
1.77
1.55
0.1267
0.03
0.32
0.14
30.65
7.14
0.2857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
613.23
-5.45
24.0
23.0
50.0
115.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050620 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Somatostatin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Dextran 70kDa conjugation
None
3-14
Glycosylation
Bio-Activity Profile
Endocrine
~0.0025 μM
IC50
Subcutaneously injected in mice, in vivo; 97200 s
PMID11778971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11778971/
RECORD: Rec_0072859 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Somatostatin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Inhibitory neuropeptide
PMID1252409 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1252409/
RECORD: Rec_0075232 VERIFIED: YES
Provenance & Taxonomy
Amia calva [Animal]
Somatostatin
7924
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Inhibitory neuropeptide
PMID8105513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8105513/
RECORD: Rec_0082498 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]; Homo sapiens [Animal]; Mus musculus [Animal]; Rattus norvegicus [Animal]
Somatostatin
9913; 9606; 10090; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
3-14
Bio-Activity Profile
Hormonal Neurotransmitter
Hippocampus tissue homogenate (SDAT brain)
Radioimmunoassay
129.8 ± 53.2 min
PaperMetabolic half-life of somatostatin and peptidase activities are altered in Alzheimer's disease
RECORD: Rec_0089976 VERIFIED: YES
Provenance & Taxonomy
Myxine glutinosa [Animal]
Somatostatin
7769
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin 14 (Myxine glutinosa): PMID 2896118##6117506 PMID2896118;6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2896118/
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