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MYP_055152
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Basic Information
Somatostatin-14
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glucagon secretion inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide
Enzyme modulation ▸ Enzyme inhibition ▸ Insulin secretion inhibition
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
14 amino acids
C76H106N18O19S2
Standard
Sequence
AGCKNFFWKTFTSC
Physicochemical Analysis
1639.89 Da
8.91
1.77
1.55
0.1267
0.03
0.32
0.14
30.65
7.14
0.2857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
613.23
-5.45
24.0
23.0
50.0
115.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0373981 VERIFIED: YES
Provenance & Taxonomy
Protopterus annectens [Animal]
Somatostatin
7888
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Protopterus annectens): PMID 6117506 PMID6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6117506/
RECORD: Rec_0374167 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
Somatostatin
9940
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-14
Bio-Activity Profile
Endocrine regulation Neurotransmission modulation Cell proliferation regulation
Intravenous infusion to cat plasma, in vivo; 144 s
PMID6128770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6128770/
RECORD: Rec_0374226 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Somatostatin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator Receptor modulation ACE inhibitory
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Homo sapiens): PMID 6117506 PMID6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6117506/
RECORD: Rec_0375962 VERIFIED: YES
Provenance & Taxonomy
Amia calva [Animal]
Somatostatin
7924
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Amia calva): PMID 8105513##6117506 PMID8105513;6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8105513/
RECORD: Rec_0386258 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
PaperGustavsson S., Lundquist G.. Inhibiton of pancreatic somatostatin release in response to glucose. Biochem. Biophys. Res. Commun., 82, 1229-1235, 1978.
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