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MYP_055152
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Basic Information
Somatostatin-14
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glucagon secretion inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitory neuropeptide
Enzyme modulation ▸ Enzyme inhibition ▸ Insulin secretion inhibition
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Inhibitory neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
14 amino acids
C76H106N18O19S2
Standard
Sequence
AGCKNFFWKTFTSC
Physicochemical Analysis
1639.89 Da
8.91
1.77
1.55
0.1267
0.03
0.32
0.14
30.65
7.14
0.2857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
613.23
-5.45
24.0
23.0
50.0
115.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0340589 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Somatostatin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-14
Bio-Activity Profile
Insulin secretion inhibition Glucagon secretion inhibition
HPLC and LC/ITMS
Bacterial strain B-9 cell culture, in vitro; 600 s
PMID22186872 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22186872/
RECORD: Rec_0363225 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Somatostatin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-14
Bio-Activity Profile
Endocrine
Radioimmunoassay
Plasma of Human patient (cirrhotic subjects), in vivo; 165 s
PMID2868381 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2868381/
RECORD: Rec_0367916 VERIFIED: YES
Provenance & Taxonomy
Canis familiaris [Animal]
Somatostatin
9615
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Inhibitory neuropeptide
PMID387385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/387385/
RECORD: Rec_0368806 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]; Homo sapiens [Animal]; Mus musculus [Animal]; Rattus norvegicus [Animal]
Somatostatin
9913; 9606; 10090; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
3-14
Bio-Activity Profile
Hormonal Endocrine regulation
Dog plasma after intravenous infusion
SS radioimmunoassay
1.7 ± 0.2 min
PaperThe in vivo metabolism of somatostatin 28: possible relationship between diminished metabolism and enhanced biological action
RECORD: Rec_0369345 VERIFIED: YES
Provenance & Taxonomy
Trachemys scripta [Animal]
Somatostatin
34903
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-14
Bio-Activity Profile
Hormone Endocrine
Experimental: 1.0±0.2 minutes; /60 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Somatostatin-14 (Trachemys scripta): PMID 1974347##6117506 PMID1974347;6117506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1974347/
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