Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2308H3657N595O720S22

DescriptionStandard

        MPLQLNSTSWILLCLLLQCLADNPGVKIQITQNGLYYGAEYLISQISSVSLSDITGSVTIASQSMDYSLTQVKMVSFQYSNSSANFIPEKGFQISIYGGNSTVNGTWQLDSSIMQDSGLSILTLKGISATVTLGMRQSNKNMVSIFLISCQSEINGIDFRVEGGVDYVYDAVKGPMENIIRSKVNEMLCSALRLQISDWDQSLSAFLSNMSLSSGLDLSLTKDPIFSKQYAEMDVKGGSDTNISMAGGHPSAPMTFSKLPDSMVQVCISEFSLNVAIRASFAANVFTNLFSGFTSFRNIRTSDLSDFLPEISQHFPEPSPVQIRIYQSTAPTLYVKPSNVTVAFVGVLQTYAMPSNTTRRLLFTATTAFSISSNISVSNKSQANGMNITGSIILSSFQLQINRNESSINIPEDVSNEKGIQDIIKVTFTTFLNEKIGKAGIYIPLDFLRNLSIYMKDRFILLAGDLQMSSDFLSS
    

Molecular Weight51965.71 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-6.34

Net Charge (pH 7.4) -6.82

Charge Density (pH 7.0) -0.0134

GRAVY Index0.10

Hydrophobic Moment 0.65

Boman Index0.14

Instability Index45.97

Aliphatic Index 95.22

Aromaticity 0.0884

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389082 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria