Peptide Database

Peptide NameBradykinin-potentiating peptide 10a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC51H73N13O14

DescriptionStandard

        QSWPGPNIPP
    

Molecular Weight1092.20 Da

Isoelectric Point (pI)5.53

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0240

GRAVY Index-1.10

Hydrophobic Moment 0.04

Boman Index0.13

Instability Index113.26

Aliphatic Index 39.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 412.26

LogP -3.68

H-bond Donors 11.0

H-bond Acceptors 14.0

Rotatable Bonds 25.0

Heavy Atoms 78.0

Ring Count 6.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0113487 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 10a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Targetthe cell

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0221945 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 10a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

TargetB2 receptor

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0247989 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 10a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Targetangiotensin-converting enzyme

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0335757 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 10a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0390691 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 10a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

TargetHEK 293 cells

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour