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MYP_055011
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Basic Information
Ranalexin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
20 amino acids
C97H169N23O22S3
Standard
Sequence
FLGGLIKIVPAMICAVTKKC
Physicochemical Analysis
2105.72 Da
9.39
2.74
2.50
0.1369
1.40
0.40
0.43
17.95
136.50
0.0500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.42
26.0
28.0
70.0
145.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213898 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
3.8 μM
MIC
PMID31426494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31426494/
RECORD: Rec_0221092 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
32 μg/mL
MIC
PMID8144672;9578480 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8144672/
RECORD: Rec_0223946 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperVignal E., Chavanieu A., Roch P., Chiche L., Grassy G., Calas B., Aumelas A.;. "Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles."; Eur. J. Biochem. 253:221-228. Evidence URLhttps://www.uniprot.org/uniprotkb/RLXN_RANCA/entry
RECORD: Rec_0235196 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
128 μg/mL
MIC
PMID8144672;9578480 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8144672/
RECORD: Rec_0241846 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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