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MYP_055011
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Basic Information
Ranalexin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
20 amino acids
C97H169N23O22S3
Standard
Sequence
FLGGLIKIVPAMICAVTKKC
Physicochemical Analysis
2105.72 Da
9.39
2.74
2.50
0.1369
1.40
0.40
0.43
17.95
136.50
0.0500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.42
26.0
28.0
70.0
145.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0043224 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii SC3033362 4-MRGN 5
15.2 μM
MIC
PMID31426494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31426494/
RECORD: Rec_0046743 VERIFIED: YES
Provenance & Taxonomy
Aquarana catesbeiana [Animal]
Ranalexin
8400
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
15.2 μM
MIC
PaperD.P. Clark et al. / The Journal of Biological Chemistry 269 (1994) 10849-10855. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, stucturally related to the bacterial antibiotic, polymyxin Evidence URLhttps://www.uniprot.org/uniprotkb/P39084/entry
RECORD: Rec_0063303 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC 29212
7.6 μM
MIC
PMID31426494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31426494/
RECORD: Rec_0084001 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Clostridium pasterianum DSM 525
7.6 μM
MIC
PMID31426494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31426494/
RECORD: Rec_0093616 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranalexin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
The recombinant ranalexin is also cytotoxic in HeLa and COS7 human cancer cells
13-15 μg/mL
IC50
PaperRanalexin, a novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin
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