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MYP_054974
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Basic Information
Cyclic Gomesin [PYA1K;C2,6,11,15SeCys;L5Y;K8R]
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KXRRYXYRQRXVTYXRGR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0140717 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
noncanonical or placeholder residue-containing peptide [Modified]
No specific N-terminal
No specific C-terminal
disulfide bond reported, sites not specified
The 'U' in sequence is SelenoCys
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Acinetobacter baumanniii ATCC 19606
1-2 μM
MIC
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0142745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
noncanonical or placeholder residue-containing peptide [Modified]
No specific N-terminal
No specific C-terminal
disulfide bond reported, sites not specified
The 'U' in sequence is SelenoCys
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
MM96L
2.3±0.2 μM
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0179857 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
noncanonical or placeholder residue-containing peptide [Modified]
No specific N-terminal
No specific C-terminal
disulfide bond reported, sites not specified
The 'U' in sequence is SelenoCys
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
PBMCs
9.5±0.5 μM
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0181372 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
noncanonical or placeholder residue-containing peptide [Modified]
None
None
X=Se-Cys
Bio-Activity Profile
Antimicrobial Anticancer
CRL-1739
46.2±7.6 μM
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0190739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
noncanonical or placeholder residue-containing peptide [Modified]
No specific N-terminal
No specific C-terminal
disulfide bond reported, sites not specified
The 'U' in sequence is SelenoCys
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer
Pseudomonas aeruginosa ATCC 27853
1 μM
MIC
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
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