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MYP_054952
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Basic Information
Gaegurin peptides SEQID NO: 1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C75H106N16O12
Standard
Sequence
FLGWLFKWAKK
Physicochemical Analysis
1423.74 Da
10.30
2.76
2.55
0.2506
0.10
0.55
0.25
4.20
80.00
0.3636
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
463.96
2.31
17.0
15.0
45.0
103.0
6.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0080010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. dysentariae
25 μg/mL
MIC
PMID21110126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21110126/
RECORD: Rec_0081261 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin/Brevinin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
A-549 (lung cancer)
25.2 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa | https://pubmed.ncbi.nlm.nih.gov/22644847/ PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0101850 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
6.3 μg/mL
MIC
PMID21110126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21110126/
RECORD: Rec_0106081 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
A-498
41.21 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0108393 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
12.5 μg/mL
MIC
PMID21110126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21110126/
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