Peptide Database

Peptide NameCecropin A-like 4 (3-18)[K2W,G5W,E9W,Q13W,H14N,T15W]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC114H163N31O18

DescriptionStandard

        LWKIWKKIWRVGWNWR
    

Molecular Weight2255.71 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.2973

GRAVY Index-0.76

Hydrophobic Moment 0.88

Boman Index-0.06

Instability Index17.20

Aliphatic Index 91.25

Aromaticity 0.3125

Extinction Coeff. Reduced 27500.00

Extinction Coeff. Oxidized 27500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 823.72

LogP 1.50

H-bond Donors 32.0

H-bond Acceptors 23.0

Rotatable Bonds 70.0

Heavy Atoms 163.0

Ring Count 10.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0422131 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCecropin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetHuman hepatocellular carcinoma HepG2

Activity0-10 % Killing

MethodKilling

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