Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length447 amino acids

Chemical FormulaC2238H3533N605O616S12

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIKVLEKELAQLKLPDISGDFRIRHVGKVRYEISRLDLRSFHLPYSRISLVPNAGLQVSISNAFAEVDGNWRVKIHFIRDHGSFDLKVENIYIKINLKLGSDASGKPTIDTSDCSTRISKVRVHFSGKFGWLYNLFHSAIESRFRKILENKVCENVVSSVRSELQPYLRTLPVTARIDAMAGIDYSLVAPPTTTAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFGASSYFFNTAGFAYHGAGALVFEITDSLVVSPRNGGLCRCPYPLPAPLQLEKMYPDMLMKLRLSASSAPFLNIGPGGLSLKPVVDIQAYAILPNSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRYGGGAAKALFCPPLSAPQVRMLQSIMNVFASSILLPRLNARLDQGFPLPLPDRIQLSNILVRFHQ
    

Molecular Weight49155.46 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)13.42

Net Charge (pH 7.4) 12.46

Charge Density (pH 7.0) 0.0300

GRAVY Index0.11

Hydrophobic Moment 0.70

Boman Index0.11

Instability Index38.81

Aliphatic Index 102.95

Aromaticity 0.0917

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409487 VERIFIED: NO

Provenance & Taxonomy

OrganismAptenodytes patagonicus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence