Peptide Database

Peptide NameCliotide T10

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antiparasitic ▸ Anthelminthic

Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC139H227N35O43S6

DescriptionStandard

        GIPCGESCVYIPCTVTALLGCSCKDKVCYKN
    

Molecular Weight3268.89 Da

Isoelectric Point (pI)7.76

Net Charge (pH 7.0)0.70

Net Charge (pH 7.4) 0.40

Charge Density (pH 7.0) 0.0226

GRAVY Index0.45

Hydrophobic Moment 0.25

Boman Index0.17

Instability Index22.46

Aliphatic Index 81.61

Aromaticity 0.0645

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1235.87

LogP -13.16

H-bond Donors 48.0

H-bond Acceptors 50.0

Rotatable Bonds 103.0

Heavy Atoms 223.0

Ring Count 4.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357734 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

FamilyCyclotide

Tax ID43366

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Other ModsN-terminal acetylation

Bio-Activity Profile

Function

Antimicrobial Anticancer Immunomodulatory Nematocidal Anthelmintic Cytotoxic

TargetHuman lung carcinoma A549

Activity0.78 μM

MethodIC50

RECORD: Rec_0359873 VERIFIED: YES