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MYP_054897
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Basic Information
Cliotide T10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H227N35O43S6
Standard
Sequence
GIPCGESCVYIPCTVTALLGCSCKDKVCYKN
Physicochemical Analysis
3268.89 Da
7.76
0.70
0.40
0.0226
0.45
0.25
0.17
22.46
81.61
0.0645
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1235.87
-13.16
48.0
50.0
103.0
223.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0156818 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID23419988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23419988/
RECORD: Rec_0173716 VERIFIED: YES
Provenance & Taxonomy
Butterfly pea [Plant]; Fabaceae [Plant]
Cyclotide
33090; 3803
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial
PMID21596752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596752/
RECORD: Rec_0186299 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
A549
0.78 μM
IC50
PMID23419988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23419988/
RECORD: Rec_0207552 VERIFIED: NO
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0258778 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Anticancer Immunomodulatory Nematocidal Anthelmintic Cytotoxic
Caenorhabditis elegans
PaperPubMed PMID 26965458 | PubMed PMID 23419980 | Serra et al. 2016 | Gilding et al. 2016 PMID26965458;23419980 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26965458/
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