Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2579H4002N642O746S19

DescriptionStandard

        MRMKAMPVLWGCFLLWNLYTSSSQTMYPGIKARVTQRALDYAVQAGLEMIEDMIKEKNLPDLNGSESLEFLKIDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTTNISTNWAIKSPLFHDSGGADLFLSEIYFTGIIILTQNDFGHPVLKLQDCYAQASHAHVSFSGELSVLYNSFAEPMEKPILKNLNGMLCPIITNEVEALNVNLSTLEVITKIDNYTLVDFSLVGPPEITEHYLDLNLKGVFYPLESLVDPPFSPVPFELPERRDSMIYIGVSEYFFKSASFAHFIAGAFGITLSTKEISKHFIQNSQGLGNVLSQIAEIYILSQPFMLQIMATEPPMVNLQPGNFTLDIPASIMMLTQPENSTLQSIVSMDFVASTSVGLAILGQRLICSLSLKRFRLSLPESNRNDIKVVRFENILSSILHFGVLPLANTRLQQGFPLPNPHKLSFINSDIEVLEGFLLISTDLKYESSSKQQPSFHGWEDLSLLNGQWTGRATP
    

Molecular Weight56546.45 Da

Isoelectric Point (pI)5.20

Net Charge (pH 7.0)-14.52

Net Charge (pH 7.4) -15.46

Charge Density (pH 7.0) -0.0286

GRAVY Index0.10

Hydrophobic Moment 0.69

Boman Index0.17

Instability Index38.79

Aliphatic Index 100.95

Aromaticity 0.1026

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0323288 VERIFIED: NO

Provenance & Taxonomy

OrganismMarmota monax [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence