Peptide Database

Peptide NameC5a des-Arg

Function Ontology

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length73 amino acids

Chemical FormulaC344H572N104O106S8

DescriptionStandard

        TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLG
    

Molecular Weight8117.38 Da

Isoelectric Point (pI)8.74

Net Charge (pH 7.0)3.51

Net Charge (pH 7.4) 3.09

Charge Density (pH 7.0) 0.0481

GRAVY Index-0.32

Hydrophobic Moment 0.62

Boman Index-0.12

Instability Index54.54

Aliphatic Index 78.90

Aromaticity 0.0411

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3444.95

LogP -38.48

H-bond Donors 126.0

H-bond Acceptors 120.0

Rotatable Bonds 281.0

Heavy Atoms 562.0

Ring Count 6.0

Amide Bonds 79.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040293 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsC5a des-ARG is one C-terminal amino acid shorter than C5a due to degradation by the serum enzyme carboxypeptidase B

Bio-Activity Profile

Function

Receptor agonist Chemotactic Immunomodulatory Signaling peptide

TargetC5a1 receptor (Human); C5a2 receptor (Human)

Activity12-36.5 nM

MethodIC50