Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length484 amino acids

Chemical FormulaC2409H3741N605O702S27

DescriptionStandard

        MLLTVIAVLMLLSCTCGENPAIQVTLTNKGLQYGKHEATDWVQKNLEDVTLPDITGEIDISVLGSIDYTLTGIRIIKCDLPEPSVEFYPDATGFKTSMLGLSVALSGEWMTHYGIIHDGGSFDMAVFSVSVSSVVELGKYADGHLSVNSVSCDAQVGDVDMEFHGGASWIVQQFVNHFKDRIRGEIEIKICPYVKKMIVNLDYHLQAMNVSFDVDQALTLDLSLTDFPFIDVSRLNLGFKGEFYSIKTHVDPPFEAQPFTMPEQQGYMLSMGLSEFTLNSASYGFYSAGGFQVLINNSMIPPGSPVHLNTSLMGPFIPQLPKMFPGLLMDLQVYATEVPMFSFQPDAVKVDFQVAVKAFAIQPNGTQTPLFKLNVDSKFISKVWISGGRAKGSVSMDNFTLMLAGSEVGPFQTDALEIMAKMGINFALAKVNQKLGKGFDLPRMKHAQLVNSVLKMQEGFVALFSDAEVLLTDRRFNRQRDGPV
    

Molecular Weight53275.86 Da

Isoelectric Point (pI)5.04

Net Charge (pH 7.0)-15.62

Net Charge (pH 7.4) -16.53

Charge Density (pH 7.0) -0.0323

GRAVY Index0.12

Hydrophobic Moment 0.65

Boman Index0.17

Instability Index30.80

Aliphatic Index 91.98

Aromaticity 0.0992

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0093525 VERIFIED: NO

Provenance & Taxonomy

OrganismSeriola dumerili [Bacterium]

FamilyBPI

Tax ID41447

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence