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MYP_054540
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Basic Information
Ano-D4,7-7C4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLLKRIXTLL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011583 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 7
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae ATCC 700603
32 μM
MIC
PMID32654770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32654770/
RECORD: Rec_0019756 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
x=D-Lys-C16 (D-Lysine with palmitoylated side group); k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Mouse erythrocytes: 10% Hemolysis=16 μM
PaperAntimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. Eur J Pharm Sci. 2020 Jan 1;141:105123. doi: 10.1016/j.ejps.2019.105123. PMID: 31676352. PMID31676352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31676352/
RECORD: Rec_0022858 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
x=D-Lys-C12 (D-Lysine with laurylated side group); k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa
128 μM
IC50
PaperAntimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. Eur J Pharm Sci. 2020 Jan 1;141:105123. doi: 10.1016/j.ejps.2019.105123. PMID: 31676352. PMID31676352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31676352/
RECORD: Rec_0023100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 7
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii ATCC 19606
4 μM
MIC
PMID32654770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32654770/
RECORD: Rec_0024292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 7
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus MR
8 μM
MIC
PMID32654770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32654770/
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