Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length442 amino acids

Chemical FormulaC2224H3523N603O615S13

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGIAILEKELAHLKLPDISGDFRIRHVGKVHYELSRLDLRSFHLPYSRISLVPNVGLQVAISNAFADVHGNWRVKIHFIRDHGSFDLKVENVYIKINLKLGSDASGKPTIDTSYCSTRISKVRVRFSGKLGWLYKLFDSAIESRFRKILESEVCEIIVRSVHRELQPYLQTLPVTAKIDAMAGVDYSLVAPPTATAQSLDVELKGECFSLAKRSAVPFPPLALSLPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSMVSPRNGDLCRCPYLVHAPPQLEEMYPDMLMKLRLSASSAPFLNIGPGGLSLTPVVDIQAYAILPNSSLAPLFLLSLVRNVSAIINIKSGHIVGSLNVGRMKLSLKHSDVGTFQVRTLQSIMNIFASSILLPRLNARLDQGFPLPLLDRVQLSNILVQFHQ
    

Molecular Weight48965.28 Da

Isoelectric Point (pI)9.23

Net Charge (pH 7.0)9.77

Net Charge (pH 7.4) 8.61

Charge Density (pH 7.0) 0.0221

GRAVY Index0.13

Hydrophobic Moment 0.78

Boman Index0.11

Instability Index40.41

Aliphatic Index 107.19

Aromaticity 0.0860

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0307583 VERIFIED: NO

Provenance & Taxonomy

OrganismHimantopus himantopus (Black-winged stilt) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria