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MYP_054275
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Basic Information
Varv peptide H
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C125H192N36O43S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCSCETWPVCSRN
Physicochemical Analysis
3079.47 Da
4.53
-1.29
-1.59
-0.0431
-0.02
0.29
0.12
41.26
32.33
0.0667
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1240.70
-18.71
48.0
48.0
90.0
210.0
6.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150025 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human lung carcinoma A549
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 10075760 PMID10075760;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0161442 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human breast adenocarcinoma MDA-MB-231
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 10075760 PMID10075760;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0175396 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-27
Bio-Activity Profile
Anticancer Cytotoxic
U251(IC50=44.70μg/mL), MDA-MB-231(IC50>10μg/mL), A549(IC50>10μg/mL), DU145(IC50>10μg/mL), BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 10075760 PMID10075760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0191445 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0201078 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human hepatocarcinoma BEL-7402
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 10075760 PMID10075760;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
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