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MYP_054224
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Basic Information
Luffin P1c
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
43 amino acids
C209H355N83O67S4
Standard
Sequence
GSPRTEYEACRVRCQVAEHGVERQRRCQQVCEKRLREREGRRE
Physicochemical Analysis
5230.83 Da
9.30
3.83
3.50
0.0891
-1.63
0.52
-0.69
67.66
40.70
0.0233
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2543.78
-32.12
97.0
76.0
184.0
363.0
3.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242088 VERIFIED: YES
Provenance & Taxonomy
Luffa aegyptiaca [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
10-31; 14-27
Bio-Activity Profile
Toxin Venom Host defense
PaperPDB 2L37 structural record; NMR; chain A; residues 1-43
RECORD: Rec_0257847 VERIFIED: NO
Provenance & Taxonomy
Luffa cylindrica [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
10-31; 14-27
Bio-Activity Profile
Ribosome-Inactivating
RECORD: Rec_0347918 VERIFIED: YES
Provenance & Taxonomy
Luffa aegyptiaca [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10-31; 14-27
Bio-Activity Profile
Antimicrobial Antiviral Toxin Cytotoxic
It exhibited ytotoxicity against uninfected C8166 cell line
235 μM
IC50
PMID9214759;21195767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9214759/
RECORD: Rec_0358347 VERIFIED: YES
Provenance & Taxonomy
Luffa cylindrica [Plant]
3670
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Ribosome-Inactivating
PaperPubMed PMID 12948831 PMID12948831 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12948831/
RECORD: Rec_0379916 VERIFIED: YES
Provenance & Taxonomy
Luffa aegyptiaca [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10-31; 14-27
Bio-Activity Profile
Antimicrobial Antiviral Toxin
PMID9214759;21195767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9214759/
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