Peptide Database

Peptide NameKiller protein of pyocin s3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length505 amino acids

Chemical FormulaC2409H3784N674O749S17

DescriptionStandard

        MLRSVVREGDATSHGGEVLAGEESLKILGKRVARIGDPVSCPKCGGNQTIIEGTPGVKCPDDQMVALEGMKTSCGATLIASQALFQVEDGGVSQFIAGYAETNTQTPTVAAAPQATAITENNARPVTPVFTKSCLRSEGCTDAGTNSEPVSNFGQTAFYQAAASVPVSAGGVTASGETGLAVMRFIGGTLASAGRWLVSTSPLGVGVMGILYSPKLNEGESDYLDSRLLETLAKQHGTAPTRVRFRWETDTNTGKLIPRGYHTSPDGGFDQVPVRMMTLNSATGHYEFWQPGENRPTILWTPNEQEFKVPSHTGNEEEPFIPSQITVLPLPDKVGSDIESLPMPEEKGFRDYILVFPADSGIKPIYVMFNTPRNQPGIVTGQGQKIEGNWLSSAGQGMGAPIPSQIADKLRGRTFNRFDDLREAIWQEVANDPEFSKQFKKLNQEDMKNGLSPYPPKSEQVGGRQKYEIHHVKFIKHGGDVYDLDNLRVITPKRHIEIHSNKEGK
    

Molecular Weight54716.99 Da

Isoelectric Point (pI)5.79

Net Charge (pH 7.0)-7.60

Net Charge (pH 7.4) -8.54

Charge Density (pH 7.0) -0.0150

GRAVY Index-0.43

Hydrophobic Moment 0.76

Boman Index0.01

Instability Index47.78

Aliphatic Index 71.82

Aromaticity 0.0713

Extinction Coeff. Reduced 49390.00

Extinction Coeff. Oxidized 49765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012205 VERIFIED: YES

Provenance & Taxonomy

OrganismPhotorhabdus khanii subsp. guanajuatensis [Bacterium]

FamilyPyocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Antibiotic Bacteriocin Hydrolase Non-hemolytic Non-ribosomal

TargetEscherichia coli (Gram-negative)

PaperPhotorhabdus khanii subsp. guanajuatensis subsp. nov., isolated from Heterorhabditis atacamensis, and Photorhabdus luminescens subsp. mexicana subsp. nov., isolated from Heterorhabditis mexicana entomopathogenic nematodes PMID30688647 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30688647/