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MYP_054115
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Basic Information
Desotamide B
Antimicrobial
Standard
6 amino acids
C34H52N8O8
Standard
Sequence
WGNVLL
Physicochemical Analysis
700.83 Da
5.53
-0.24
-0.44
-0.0400
1.17
0.39
0.62
-23.10
178.33
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
267.70
-0.20
9.0
8.0
20.0
50.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068571 VERIFIED: YES
Provenance & Taxonomy
Streptomyces scopuliridis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
APD analysis reveals that the sequence of Dosotamide A shows 83.3% similarity to bacterial Baceridin. L5 is a D-amino acid. Active against S. aureus (MIC 16 ug/ml), S. pneumiae NCTC 7466 (MIC 12.5 ug/ml), and methicillin-resistant S. epidermidis shhs-E1 (MIC 32 ug/ml)
Bio-Activity Profile
Antimicrobial
S. pneumiae NCTC 7466
12.5 μg/mL
MIC
PaperCyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
RECORD: Rec_0198676 VERIFIED: YES
Provenance & Taxonomy
Streptomyces scopuliridis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
APD analysis reveals that the sequence of Dosotamide A shows 83.3% similarity to bacterial Baceridin. L5 is a D-amino acid. Active against S. aureus (MIC 16 ug/ml), S. pneumiae NCTC 7466 (MIC 12.5 ug/ml), and methicillin-resistant S. epidermidis shhs-E1 (MIC 32 ug/ml)
Bio-Activity Profile
Antimicrobial
methicillin-resistant Staphylococcus epidermidis shhs-E1
32 μg/mL
MIC
PaperCyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
RECORD: Rec_0288052 VERIFIED: YES
Provenance & Taxonomy
Streptomyces scopuliridis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
APD analysis reveals that the sequence of Dosotamide A shows 83.3% similarity to bacterial Baceridin. L5 is a D-amino acid. Active against S. aureus (MIC 16 ug/ml), S. pneumiae NCTC 7466 (MIC 12.5 ug/ml), and methicillin-resistant S. epidermidis shhs-E1 (MIC 32 ug/ml)
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
16 μg/mL
MIC
PaperCyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
RECORD: Rec_0368167 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0390881 VERIFIED: YES
Provenance & Taxonomy
Streptomyces scopuliridis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/