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MYP_053927
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Basic Information
Defensin-like turtle egg white protein TEWP (TEWP)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
36 amino acids
C177H297N53O45S6
Standard
Sequence
QKKCPGRCTLKCGKHERPTLPYNCGKYICCVPVKVK
Physicochemical Analysis
4079.97 Da
9.54
7.78
7.43
0.2162
-0.61
0.52
-0.21
31.60
56.67
0.0556
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1585.68
-14.97
60.0
60.0
134.0
281.0
7.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0274462 VERIFIED: YES
Provenance & Taxonomy
Caretta caretta [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0309349 VERIFIED: YES
Provenance & Taxonomy
Caretta caretta [Animal]
beta-defensin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
4-30; 8-29; 12-24
Bio-Activity Profile
Antimicrobial beta-defensin family Antibacterial Host defense Defensin-like
PaperPDB 2B5B structural record; NMR; chain A; residues 2-36
RECORD: Rec_0332322 VERIFIED: YES
Provenance & Taxonomy
Caretta caretta [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Staphylococcus aureus
5 μM
IC50
PaperPubMed PMID: 16700051 PMID16700051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16700051/
RECORD: Rec_0337039 VERIFIED: YES
Provenance & Taxonomy
Red sea turtle [other]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
C1-C6; C2-C5; C3-C4, different from those of the vertebrate beta-defensins. The protein showed strong antibacterial activity against E. coli and S. typhimurium as well as an enveloped rhabdovirus, Chandipura virus, which is an emerging human pathogen. You can rotate, zoom, and view the 3D structure here in the PDB. Updated 12/2014; 9/2018
Bio-Activity Profile
Antimicrobial Antiviral
PaperSmall cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity.
RECORD: Rec_0418737 VERIFIED: YES
Provenance & Taxonomy
Caretta caretta [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
Escherichia coli
3.3 μM
IC50
PaperPubMed PMID: 16700051 PMID16700051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16700051/
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