Peptide Database

Peptide Namekappa-Theraphotoxin-Tb1a

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC178H272N54O50S7

DescriptionStandard

        AACLGMFESCDPNNDKCCPNRECNRKHKWCKYKLW
    

Molecular Weight4192.85 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)2.83

Net Charge (pH 7.4) 2.49

Charge Density (pH 7.0) 0.0807

GRAVY Index-1.04

Hydrophobic Moment 0.50

Boman Index-0.29

Instability Index74.83

Aliphatic Index 28.00

Aromaticity 0.1143

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1711.32

LogP -17.06

H-bond Donors 64.0

H-bond Acceptors 61.0

Rotatable Bonds 137.0

Heavy Atoms 289.0

Ring Count 9.0

Amide Bonds 38.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0134442 VERIFIED: NO

Provenance & Taxonomy

OrganismTheraphosa blondi [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-18; 10-23; 17-30

Bio-Activity Profile

Function

Toxin

TargetKv4

RECORD: Rec_0408534 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 22.9%, T 34.3%, C 42.9% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic