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MYP_053867
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Basic Information
Isracidin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Standard
23 amino acids
C125H203N39O32
Standard
Sequence
RPKHPIKHQGLPQEVLNENLLRF
Physicochemical Analysis
2764.19 Da
9.99
1.94
1.63
0.0843
-0.99
0.38
-0.21
46.49
97.39
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1157.31
-8.93
37.0
36.0
91.0
196.0
6.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0181826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
E. sakazakii
500 μg/mL
MIC
PaperAntimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum
RECORD: Rec_0189012 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2009/0214498 A1 Evidence URLhttps://patents.google.com/patent/US20090214498A1/en PatentUS 2009/0214498 A1
RECORD: Rec_0225211 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperLahov E., Regelson W.. Antibacterial and immunostimulating casein-derived substances from milk:casecidin, isracidin peptides. Food Chem. Toxicol., 34(1), 131-145 (1996).
RECORD: Rec_0262405 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
36.2 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0270059 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli DH5alpha or DPC6053
200 μg/mL
MIC
PaperAntimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum
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