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MYP_053867
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Basic Information
Isracidin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Standard
23 amino acids
C125H203N39O32
Standard
Sequence
RPKHPIKHQGLPQEVLNENLLRF
Physicochemical Analysis
2764.19 Da
9.99
1.94
1.63
0.0843
-0.99
0.38
-0.21
46.49
97.39
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1157.31
-8.93
37.0
36.0
91.0
196.0
6.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132130 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0135020 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Immunomodulator Anti-Gram-negative
Escherichia coli
200 μg/mL
MIC
RECORD: Rec_0148640 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Casecidin
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPeptidomic analysis reveals proteolytic activity of kefir microorganisms on bovine milk proteins; Antibacterial and immunostimulating casein-derived substances from milk: casecidin, isracidin peptides PMID26616950;8603791 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26616950/
RECORD: Rec_0151209 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory
PaperLahov E., Regelson W.. Antibacterial and immunostimulating casein-derived substances from milk:casecidin, isracidin peptides. Food Chem. Toxicol., 34(1), 131-145 (1996).
RECORD: Rec_0181826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
E. sakazakii
500 μg/mL
MIC
PaperAntimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum
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