Peptide Database

Peptide NameSLAY-screened peptide P4925

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H162N26O31S3

DescriptionStandard

        CHYDIFHNCSMDYSIFLKYL
    

Molecular Weight2512.88 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-1.09

Net Charge (pH 7.4) -1.43

Charge Density (pH 7.0) -0.0544

GRAVY Index0.14

Hydrophobic Moment 0.28

Boman Index0.20

Instability Index65.77

Aliphatic Index 78.00

Aromaticity 0.2500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 918.44

LogP -4.39

H-bond Donors 34.0

H-bond Acceptors 35.0

Rotatable Bonds 78.0

Heavy Atoms 176.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0379510 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/