Peptide Database

Peptide NamePhylloseptin-S4 (PLS-S4)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC335H537N85O105S3

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKRETEEEEHDQEEDDKSEEKRFLSMIPHIVSGVAALAKHLG
    

Molecular Weight7531.55 Da

Isoelectric Point (pI)4.80

Net Charge (pH 7.0)-7.22

Net Charge (pH 7.4) -7.63

Charge Density (pH 7.0) -0.1093

GRAVY Index-0.20

Hydrophobic Moment 0.68

Boman Index0.01

Instability Index69.07

Aliphatic Index 100.45

Aromaticity 0.0606

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3056.19

LogP -23.38

H-bond Donors 105.0

H-bond Acceptors 104.0

Rotatable Bonds 265.0

Heavy Atoms 528.0

Ring Count 8.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012391 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Antiparasitic Cytolytic Hemolytic

TargetLeishmania species

RECORD: Rec_0168958 VERIFIED: NO