Peptide Database

Peptide NameBradykinin-potentiating peptide 12c

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC72H102N20O16

DescriptionStandard

        QWAQWPRPQIPP
    

Molecular Weight1503.70 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0633

GRAVY Index-1.41

Hydrophobic Moment 0.32

Boman Index-0.08

Instability Index36.11

Aliphatic Index 40.83

Aromaticity 0.1667

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 571.01

LogP -2.67

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 38.0

Heavy Atoms 108.0

Ring Count 8.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0073616 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 12c

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods4:Pyrrolidone carboxylic acid

Bio-Activity Profile

Function

Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Targetangiotensin-converting enzyme

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0118334 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 12c

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods4:Pyrrolidone carboxylic acid

Bio-Activity Profile

Function

Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0339728 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic