‹ ›
MYP_053713
← PREVIOUS NEXT → BACK
Basic Information
C18-p1b
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Standard
15 amino acids
C88H131N27O20
Standard
Sequence
DFRRLPGAFWQLRQP
Physicochemical Analysis
1887.15 Da
11.70
1.76
1.56
0.1174
-0.90
0.64
-0.24
88.19
58.67
0.2000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
778.11
-5.05
27.0
22.0
57.0
135.0
6.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0017127 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0149661 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Alkylated(C18)
Bio-Activity Profile
Antiviral Anti-H3N2 Binding inhibition
H3N2 (A/Aichi/2/68)
19 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 Jul 23;52(14):4247-56. | DOI:10.1021/jm801570y | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0176303 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
H3N2(A/Aichi/2/68):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells
19 μM
IC50
PaperPubMed PMID: 19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0267706 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Alkylated(C18)
Amidation
Alkylated(C18)
Bio-Activity Profile
Antiviral Anti-H1N1 Binding inhibition
H1N1 (A/PR/8/34)
52 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 Jul 23;52(14):4247-56. | DOI:10.1021/jm801570y | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
RECORD: Rec_0295549 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Influenza A virus (Virus entry); B16
52 μM
Plaque assay
PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2