Peptide Database

Peptide NameestB signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Hydrolase ▸ Glycosidase ▸ Xylanase

Enzyme / Catalytic activity ▸ Hydrolase ▸ Lipase

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC134H233N31O32S3

DescriptionStandard

        MKKVLMAFIICLSLILSVLAAPPSGAKA
    

Molecular Weight2886.67 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)2.49

Net Charge (pH 7.4) 2.25

Charge Density (pH 7.0) 0.0888

GRAVY Index1.48

Hydrophobic Moment 0.30

Boman Index0.47

Instability Index42.38

Aliphatic Index 150.00

Aromaticity 0.0357

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 970.19

LogP -4.05

H-bond Donors 34.0

H-bond Acceptors 38.0

Rotatable Bonds 95.0

Heavy Atoms 200.0

Ring Count 3.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0372540 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization alpha-amylase (AmyS) secretion

TargetBacillus subtilis 1A751p

Activity1238.25 U/mL

MethodAmylase activity assay

PaperFu G, Liu J L, Li J S, et al. Systematic Screening of Optimal Signal Peptides for Secretory Production of Heterologous Proteins in Bacillus subtilis[J]. Journal of Agricultural and Food Chemistry, 2018, 66(50): 13141-13151. PMID30463403 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30463403/

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